PENCEGAHAN VENTILATOR-ASSOCIATED PNEUMONIA DENGAN PEMBERIAN PROFILAKSIS STRESS ULCERS

Adinta Anandani

Abstract


Abstrak : Ventilator-associated pneumonia (VAP) adalah pneumonia yang terjadi lebih dari 48 jam setelah pemasangan intubasi endotrakeal akibat dari mikroorganisme yang masuk saluran pernapasan bagian bawah melalui aspirasi sekret orofaring yang berasal dari bakteri endemik di saluran pencernaan atau patogen eksogen yang diperoleh dari peralatan yang terkontaminasi atau petugas kesehatan. Terapi dengan menggunakan proton pump inhibitor sebagai profilaksis terhadap stress ulcer yang mungkin ditimbulkan akibat pemakaian ventilator mekanik mungkin terkait dengan peningkatan risiko terjadinya hospital acquired pneumonia (HAP). Berdasarkan data–data komparatif dari beberapa penelitian randomized IDSA (2005) merekomendasikan penggunaan sukralfat dibandingkan dengan H2-blocker dalam PSU untuk mengurangi kemungkinan timbulnya VAP.

 

Abstract: Ventilator-associated pneumonia (VAP) is pneumonia that occurs more than 48 hours after endotracheal intubation due to microorganisms that enter the lower respiratory tract by aspiration of secretions oropharynx derived from endemic bacteria in the digestive tract or pathogen exogenous obtained from contaminated devices or health workers. Therapy using proton pump inhibitors as prophylaxis against stress ulcer (PSU) which may be incurred as a result of the use of a mechanical ventilator may be associated with an increased risk of hospital acquired pneumonia (HAP). Based on comparative data from several randomized studies IDSA (2005) recommends the use of sucralfate compared with H2-blockers in the PSU to reduce the likelihood of onset VAP.


Keywords


Ventilator-associated pneumonia

Full Text:

PDF

References


American Thoracic S, Infectious Diseases Society of A. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005;171:388-416. 2. Prescott HC, O'Brien JM. Prevention of ventilator-associated pneumonia in adults. F1000 medicine reports 2010;2. 3. Alhazzani W, Alshahrani M, Moayyedi P, Jaeschke R. Stress ulcer prophylaxis in critically ill patients: review of the evidence. Pol Arch Med Wewn 2012;122:107-14. 4. Guillamondegui O, Gunter J, OL, Bonadies Jea. Practice Management Guidelines For Stress Ulcer Prophylaxis. In: Eastern Association for the Surgery of Trauma; 2008:1-24. 5. IHI Ventilator Bundle: Peptic Ulcer Disease Prophylaxis. In: Institute for Healthcare Improvement.; 2014. 6. Cook DJ, Fuller HD, Guyatt GH, Marshall JC, Leasa D, Hall R, et al. Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group. N Engl J Med 1994;330:377-81. 7. Ellison RT, Perez-Perez G, Welsh CH, Blaser MJ, Riester KA, Cross AS, et al. Risk factors for upper gastrointestinal bleeding in intensive care unit patients: role of helicobacter pylori. Federal Hyperimmune Immunoglobulin Therapy Study Group. Crit Care Med 1996;24:1974-81. 8. Leonard J, Marshall JK, Moayyedi P. Systematic review of the risk of enteric infection in patients taking acid suppression. Am J Gastroenterol 2007;102:2047-56; quiz 57. 9. Eddleston JM, Vohra A, Scott P, Tooth JA, Pearson RC, McCloy RF, et al. A comparison of the frequency of stress ulceration and secondary pneumonia in sucralfate- or ranitidine-treated intensive care unit patients. Crit Care Med 1991;19:1491-6. Bonten MJ, Gaillard CA, van Tiel FH, van der Geest S, Stobberingh EE. Continuous enteral feeding counteracts preventive measures for gastric colonization in intensive care unit patients. Crit Care Med 1994;22:939-44.




DOI: https://doi.org/10.32667/ijid.v2i1.20

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The Indonesian Journal of Infectious Disese (IJID) has been covered by these following indexing services.

 Google Scholar  Mendeley

 


Secretariat Address :

Research Instalation

Sulianti Saroso Infectious Disease Hospital

Jl. Baru Sunter Permai Raya, Jakarta Utara 143040

Telp : (021) 6506559  ext 3119

www. ijid-rspisuliantisaroso.co.id

Email : jurnal@ijid-rspisuliantisaroso.co.id