Hubungan Antara Kadar Vitamin D dengan Derajat Keparahan COVID-19
Downloads
Latar belakang: Vitamin D merupakan salah satu vitamin yang dapat melalui penghambatan respons sel T helper tipe 1 dan merangsang induksi sel T. Hal ini menunjukkan efek perlindungan vitamin D terhadap status infeksi virus pernapasan pada pasien COVID-19. Tujuan: mengetahui hubungan antara kadar Vitamin D dengan derajat penyakit COVID-19. Metode: rancangan penelitian deskriptif korelasional dengan metode analitik melalui pendekatan cross sectional. Total sampel 547 sampel pasien COVID-19 RSPI Sulianti Saroso periode Maret-Desember Tahun 2020. Hasil: Jumlah pasien rawat inap tahun 2020 sebanyak 547 pasien COVID-19, rata-rata usia 47,74 tahun, jenis kelamin laki-laki (55%), dengan komorbid (penyakit penyerta) (58,7%), rata-rata vitamin D 17.94 ng/ml dalam kategori defisiensi < 20 ng/ml (64,2%), derajat keparahan sedang (81,9%). Hasil uji chi square diperoleh nilai p value 0,518 (> 0,05) dengan menggunakan alpha 5% (0,05) berarti tidak ada hubungan antara Vitamin D dengan derajat keparahan pada pasien COVID-19 Kesimpulan: Kadar Vitamin D tidak berhubungan dengan derajat keparahan COVID-19
Downloads
World Health Organization. Naming the Coronavirus Disease (COVID-19) and the Virus That Causes It.; 2020.
Wijayanti UT. Pandemi Covid-19. Anal Fakt Penyebab Perceraioan Pada Masa Pandemi Covid-19 Di Kabupaten Banyumas. 2021;14:20.
Kemenkes RI. Pedoman Kesiapsiagaan Menghadapi Coronavirus Disease (COVID-19). Direktorat Jenderal Pencegah dan Pengendali Penyakit. Published online 2020.
Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-1242. doi:10.1001/jama.2020.2648
Cheng L, Li H, Li L, et al. Ferritin in the coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. J Clin Lab Anal. 2020;34(10). doi:10.1002/jcla.23618
Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020;13(10):1373-1380. doi:10.1016/j.jiph. 2020.06.021
Herr C, Greulich T, Koczulla RA, et al. The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer. Respir Res. 2011;12(1):31. doi:10.1186/1465-9921-12-31
Rojas M, RodrÃguez Y, Monsalve DM, et al. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19. The COVID-19 resource center is hosted on Elsevier Connect, the company's public news and information. Autoimmun Rev. 2020;(January).
Sabetta JR, Depetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML. Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults. PLoS One. 2010;5(6). doi:10.1371/ journal.pone.0011088
Abdulateef DS, Rahman HS, Salih JM, et al. COVID-19 severity in relation to sociodemographics and vitamin D use. Open Med. 2021;16(1):591-609. doi:10.1515/ med-2021-0273
Carpagnano GE, Di Lecce V, Quaranta VN, et al. Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. J Endocrinol Invest. 2021;44(4):765-771. doi:10.1007/ s40618-020-01370-x
Rohith M, Monika N, Rajanna A, Ravi K. Study of impact of comorbidities on patients with COVID-19 infection. APIK J Intern Med. 2021;9(4):233. doi:10.4103/ ajim.ajim_69_21
Wang B, Li R, Lu Z, Huang Y. Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis. Aging (Albany NY). 2020;12(7):6049-6057. doi:10. 18632/aging.103000
Sanyaolu A, Okorie C, Marinkovic A, et al. Comorbidity and its Impact on Patients with COVID-19. SN Compr Clin Med. Published online June 2020:1-8. doi:10.1007/ s42399-020-00363-4
Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA Netw Open. 2020;3(9). doi:10.1001/ jamanetworkopen.2020.19722
Liao EP. Vitamin D and Diabetes. Contemp Endocrinol. Published online 2018:135-149. doi:10.1007/ 978-3-319-73742-3_7
Ghasemian R, Shamshirian A, Heydari K, et al. The role of vitamin D in the age of COVID-19: A systematic review and meta-analysis. Int J Clin Pract. 2021;75(11):1-16. doi:10.1111/ ijcp.14675
Baktash V, Hosack T, Patel N, et al. Vitamin D status and outcomes for hospitalised older patients with COVID-19. Postgrad Med J. 2021;97(1149):442-447. doi:10. 1136/postgradmedj-2020-138712
Davoudi A, Najafi N, Aarabi M, et al. Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection. BMC Infect Dis. 2021;21(1):1-7. doi:10.1186/s12879 -021-06168-7
Ramadan HKA, Mahmoud MA, Zakaria M, et al. Predictors of severity and co-infection resistance profile in COVID-19 patients: First report from upper Egypt. Infect Drug Resist. 2020;13:3409-3422. doi:10. 2147/IDR.S272605
Bozkurt FT, Tercan M, Patmano G, Bingol Tanrıverdi T, Demir HA, Yurekli UF. Can Ferritin Levels Predict the Severity of Illness in Patients With COVID-19? Cureus. 2021;13(1):1-8. doi:10.7759/cureus. 12832
Vasheghani M, Jannati N, Baghaei P, Rezaei M, Aliyari R, Marjani M. The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality.Sci Rep. 2021;11(1). doi:10.1038/s41598-021-97017-9
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223): 497-506. doi:10. 1016/S0140-6736(20)30183-5
Ali S. Combatting Against Covid-19 & Misinformation: A Systematic Review. Hum Arenas. 2020;(0123456789). doi:10.1007/ s42087-020-00139-1
Tian Y, Rong L. Letter: Covid-19, and vitamin D. Authors’ reply. Aliment Pharmacol Ther. 2020;51(10):995-996. doi:10.1111/ apt.15764
