Ko-Infeksi TB-HIV terhadap Kegagalan Pengobatan Pasien Tuberkulosis Resistan Obat di Indonesia
Downloads
Latar belakang: Tuberkulosis merupakan infeksi oportunistik utama di antara orang dengan infeksi HIV. Berdasarkan data Kemenkes RI bahwa prevalensi ko-infeksi TB-HIV pada pasien Tuberkulosis Resisten Obat (TB RO) di Indonesia tahun 2021-2022 sebanyak 3,1%. Sedangkan angka kegagalan pengobatan TB RO berkisar 50–55% (target 20%) di Indonesia. Tujuan: Menganalisis ko-infeksi TB-HIV terhadap kegagalan pengobatan pasien TB RO di Indonesia. Metode: Desain studi penelitian ini menggunakan kohort retrospektif dengan data Sistem Informasi Tuberkulosis (SITB) tahun 2022-2023 di Indonesia dengan total sampling sebanyak 4.261 subyek. Analisis data dilakukan dengan uji chi-square, uji stratifikasi dan regresi logistik berganda dengan metode backward. Hasil: Sebanyak 68,0% pasien TB RO dengan ko-infeksi TB-HIV mengalami kegagalan pengobatan di Indonesia pada tahun 2022-2023. Pasien ko-infeksi TB-HIV memiliki risiko 2,3 kali lebih besar (95% CI: 1,6 – 3,2) untuk mengalami kegagalan pengobatan TB RO dibandingkan pasien tanpa ko-infeksi TB-HIV setelah dikontrol variabel usia. Kesimpulan: Pasien ko-infeksi TB-HIV memiliki risiko lebih tinggi terhadap terjadinya kegagalan pengobatan TB RO di Indonesia.
Downloads
Bhargava A, Bhargava M, Pai M. Tuberculosis: a biosocial problem that requires biosocial solutions. The Lancet. 2024 Jun 8;403(10443):2467–9.
Kemenkes RI. Kepmenkes No. HK.01.07/Menkes/755/2019 Tentang Pedoman Nasional Pelayanan Kedokteran Tatalaksana Tuberkulosis. 2019.
Forsman LD, Schön T, Simonsson USH, Bruchfeld J, Larsson M, Juréen P, et al. Intra- And extracellular activities of trimethoprim-sulfamethoxazole against susceptible and multidrug-resistant Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2014 Dec 1;58(12):7557–9.
Kemenkes RI. Petunjuk Teknis Penatalaksanaan Tuberkulosis Resistan Obat di Indonesia. 2024.
Kemenkes RI. Laporan Program Penanggulangan Tuberkulosis Tahun 2022. 2022.
Handari RD. Analisis Survival: Hubungan Komorbid HIV Terhadap Kematian Pasien Tuberkulosis Resistan Obat Dewasa di Indonesia tahun 2021-2022. Universitas Indonesia; 2024.
Muluneh MA, Zeru AB, Derseh BT, Molla Kebede A. Survival Status and Predictors of Mortality among Multidrug-Resistant Tuberculosis Patients in Saint Peter’s Specialized Hospital, Addis Ababa, Ethiopia. Canadian Journal of Infectious Diseases and Medical Microbiology [Internet]. 2021 [cited 2024 Nov 18];2021. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8437643/#sec4
Mollel EW, Chilongola JO. Predictors for Mortality among Multidrug-Resistant Tuberculosis Patients in Tanzania. J Trop Med [Internet]. 2017 [cited 2024 Nov 18]; 2017:9241238. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5541808/
Moges S, Lajore BA. Mortality and associated factors among patients with TB-HIV co-infection in Ethiopia: a systematic review and meta-analysis. BMC Infect Dis [Internet]. 2024 Dec 1 [cited 2024 Nov 18];24(1):1–14. Available from: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09683-5.
Tola A, Mishore KM, Ayele Y, Mekuria AN, Legese N. Treatment Outcome of Tuberculosis and Associated Factors among TB-HIV Co-Infected Patients at Public Hospitals of Harar Town, Eastern Ethiopia. A five-year retrospective study. BMC Public Health [Internet]. 2019 Dec 10 [cited 2024 Nov 18];19(1). Available from: https://pubmed.ncbi.nlm.nih.gov/31822286/
Belachew T, Yaheya S, Tilahun N, Gebrie E, Seid R, Nega T, et al. Multidrug-Resistant Tuberculosis Treatment Outcome and Associated Factors at the University of Gondar Comprehensive Specialized Hospital: A Ten-Year Retrospective Study. Infect Drug Resist. 2022;15:2891–9.
Bastos ML, Cosme LB, Fregona G, do Prado TN, Bertolde AI, Zandonade E, et al. Treatment outcomes of MDR-tuberculosis patients in Brazil: A retrospective cohort analysis. BMC Infect Dis. 2017 Nov 14;17(1).
Keng Tok PS, Liew SM, Wong LP, Razali A, Loganathan T, Chinna K, et al. Determinants of unsuccessful treatment outcomes and mortality among tuberculosis patients in Malaysia: A registry-based cohort study. PLoS One. 2020 Apr 1;15(4).
Boillat-Blanco N, Ramaiya KL, Mganga M, Minja LT, Bovet P, Schindler C, et al. Transient hyperglycemia in patients with tuberculosis in Tanzania: Implications for diabetes screening algorithms. Journal of Infectious Diseases [Internet]. 2016 Apr 1 [cited 2024 Nov 18];213(7):1163–72. Available from: https://academic.oup.com/jid/article/213/7/1163/2912154
Wulandari EB. Analisis Keberhasilan Paduan Pengobatan Menggunakan Bedaquiline Pada Pasien Tuberkulosis Resisten Obat Provinsi DKI Jakarta. Universitas Indonesia; 2024.
Hasanah NA. Faktor-Faktor yang Berhubungan dengan Kematian pada Pasien Tuberkulosis Multi Drug Resistance (TB-MDR) Selama Masa Pengobatan di Indonesia Tahun 2010-2014 [Internet]. Universitas Indonesia; 2017 [cited 2024 Nov 5]. Available from: https://lib.ui.ac.id/ detail.jsp?id=20457345.
Wells CD, Cegielski JP, Nelson LJ, Laserson KF, Holtz TH, Finlay A, et al. HIV infection and multidrug-resistant tuberculosis - The perfect storm. In: Journal of Infectious Diseases. 2007.
Koroma JA, Elduma AH, Sesay U, Gebru GN. Factors associated with unfavorable treatment outcomes among multidrug-resistant tuberculosis patients, Sierra Leone: a cross-sectional secondary data analysis. BMC Infect Dis. 2024 Dec 1;24(1).
Copyright (c) 2024 The Indonesian Journal of Infectious Diseases

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.